Our major scientific achievements over the last 5 years
Here we present 10 selected papers with CanCell scientists as lead authors, and a list of the most prestigious grants obtained by CanCell scientists since the opening of the centre in 2018. Scientific highlights for 2022 are listed groups wise in the 'Research Groups' section.
Research Articles
Ng MYW, Charsou C, Lapao A, Singh S, Trachsel-Moncho L, Schultz SW, Nakken S, Munson MJ, Simonsen A. The cholesterol transport protein GRAMD1C regulates autophagy initiation and mitochondrial bioenergetics. Nat Commun. 2022 Oct 21;13(1):6283. PMID: 36270994.
“Behind the paper” blog at Nature Portfolio Communities : GRAMD1C-mediated cholesterol transport regulates autophagosome biogenesis and mitochondrial bioenergetics
Fiorito E#, Szybowska P#, Haugsten EM, Kostas M, Øy GF, Wiedlocha A, Singh S, Nakken S, Mælandsmo GM, Fletcher JA, Meza-Zepeda LA and Wesche J. Strategies to inhibit FGFR4 V550L-driven rhabdomyosarcoma. British Journal of Cancer 2022 127: 1939–1953. PMID: 36097178
#, shared first authors.
Sharma, A, Akshay, A, Rogne, M, and Eskeland, R. ShinyArchR.UiO: user-friendly,integrative and open-source tool for visualization of single-cell ATAC-seq data using ArchR. Bioinformatics 2022 38, 834-836. PMID: 34586377
Munson MJ, Mathai BJ, Ng MYW, Trachsel-Moncho L, de la Ballina LR, Schultz SW, Aman Y, Lystad AH, Singh S, Singh S, Wesche J, Fang EF, Simonsen A. GAK and PRKCD are positive regulators of PRKN-independent mitophagy. Nat Commun. 2021 Oct 20;12(1):6101. PMID: 34671015.
- Selected for Nature Communications Editors’ Highlights webpage “From molecules and cells to organisms”
- Selected Editor’s corner Autophagy; Lei Y, Klionsky DJ. New regulators of PRKN-independent mitophagy. Autophagy.
- preLights - GAK and PRKCD are positive regulators of PRKN-independent mitophagy
Khezri R, Holland P, Schoborg TA, Abramovich I, Takáts S, Dillard C, Jain A, O'Farrell F, Schultz SW, Hagopian WM, Quintana EM, Ng R, Katheder NS, Rahman MM, Teles Reis JG, Brech A, Jasper H, Rusan NM, Jahren AH, Gottlieb E, Rusten TE. Host autophagy mediates organ wasting and nutrient mobilization for tumor growth. EMBO Journal 2021 Sep 15;40(18). PMID: 34309071
Agudo-Canalejo J#, Schultz SW#, Chino H, Migliano SM, Saito C, Koyama-Honda I, Stenmark H, Brech A, May AI, Mizushima N and Knorr RL. Wetting regulates autophagy of phase-separated compartments and the cytosol. Nature 2021 591: 142-146. PMID: 33473217
#, shared first authors. *, shared corresponding authors
Vietri M, Schultz SW, Bellanger A, Jones CM, Petersen LI, Raiborg C, Skarpen E, Pedurupillay CRJ, Kjos I, Kip E, Timmer R, Jain A, Collas P, Knorr RL, Grellscheid SN, Kusumaatmaja H, Brech A, Micci F, Stenmark H* and Campsteijn C*. Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation. Nature Cell Biololgy 2020 22: 856-867. PMID: 32601372
*, shared corresponding authors
Lystad AH, Carlsson SR, de la Ballina LR, Kauffman KJ, Nag S, Yoshimori T, Melia TJ, Simonsen A. Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes. Nat Cell Biol. 2019 Mar;21(3):372-383. PMID: 30778222.
Sneeggen M, Pedersen NM, Campsteijn C, Haugsten EM, Stenmark H* and Schink KO*. WDFY2 restrains matrix metalloproteinase secretion and cell invasion by controlling VAMP3-dependent recycling. Nature Communications 2019 10: 2850. PMID: 31253801
*, shared corresponding authors
Kruitwagen T#, Chymkowitch P#, Denoth-Lippuner A, Enserink JM, Barral Y. Centromeres License the Mitotic Condensation of Yeast Chromosome Arms. Cell 2018 175(3):780-795. doi: 10.1016/j.cell.2018.09.012. PMID: 30318142
#, shared first authors.
CanCell Publications
Grants
Here we include a list of the prestigious grants obtained by CanCell scientists since the opening of the centre in 2018, including two ERC grants, two EU ITN grants, three EEA Norway grants, two RCN “Toppforsk” grants, an RCN Large Interdisciplinary Project, three UiO Convergence Environment Grants from UiO Life Science, three RCN Young Talents grants and two HSØ career grants. CanCell’s success in promoting the careers of young researchers is demonstrated by the award of 5 large-scale career grants